Rapid growing of population, limitation of space, economic and social parameters are reasons that have led to the construction of Tall buildings. On the other hand, due to invention of strong and lightweight materials, Tall buildings had low damping ratio and long vibrational periods. For this reasons, it is necessary to investigate and analyze Tall buildings under wind loads. In the present research, wind-Structure interaction is performed on standard Tall building CAARC using computational fluid dynamics (CFD), computational structural dynamics (CSD) and ABAQUS finite element software. The wind mean velocity profile is modelled using exponential formula in the boundary layer of atmosphere, wind turbulence is simulated using implicit large eddy simulation method (ILES), and co-simulation method is used to transfer non-uniform loads from fluid domain to structural nodes. Structural damping is determined by Rayleigh method. To validate the modelling, results are compared with reliable numerical and experimental findings. Results show that non-damped Structures have responses significantly higher than damped Structures. It is concluded that the distribution of the average wind pressure in high-rise buildings is influenced by the average wind speed. Therefore, in order to assurance in the design of Tall Structures, mechanical properties of wind and Structure must be considered.